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compared with the Regulate group. In LoVo cells, the protein expression amounts of matrix metallopeptidases, snail family transcriptional repressor one, Vimentin and N-cadherin have been drastically downregulated, whereas the protein expression amounts of E-cadherin were being drastically upregulated by lycorine remedy in contrast With all the cont

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Our recent studies suggest this is due to faulty trafficking of late endosomes to lysosomes, with concomitant homotypic fusion with the influenced vesicular compartments [5]. The defect in lysosome-directed trafficking also influences autophagic flux, with resultant accumulation of autophagosomes [5]. In the end, the integrity from the cell membran

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